Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas Running Title: Dual inhibition of PI3K and mTOR in PEL
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چکیده
PI3K/Akt/mTOR-addicted lymphomas Running Title: Dual inhibition of PI3K and mTOR in PEL Aadra P. Bhatt*, Prasanna M. Bhende*, Sang-Hoon Sin, Debasmita Roy, Dirk P. Dittmer and Blossom Damania^. *A.P.B. and P.M.B. contributed equally to this study. Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 ^Corresponding author. Mailing address: Lineberger Comprehensive Cancer Center, CB#7295, University of North Carolina, Chapel Hill, NC 27599. Phone: (919) 843-6011. Fax: (919) 9669673. E-mail: [email protected]. Blood First Edition Paper, prepublished online March 18, 2010; DOI 10.1182/blood-2009-10-251082
منابع مشابه
Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas.
Primary effusion lymphoma (PEL) constitutes a subset of non-Hodgkin lymphoma whose incidence is highly increased in the context of HIV infection. Kaposi sarcoma-associated herpesvirus is the causative agent of PEL. The phosphatidylinositol 3-kinase (PI3K) signaling pathway plays a critical role in cell proliferation and survival, and this pathway is dysregulated in many different cancers, inclu...
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Primary effusion lymphoma (PEL) constitutes a subset of non-Hodgkin lymphoma whose incidence is highly increased in thecontextofHIV infection.Kaposisarcoma– associated herpesvirus is the causative agent of PEL. The phosphatidylinositol 3-kinase (PI3K) signaling pathway plays a critical role in cell proliferation and survival, and this pathway is dysregulated in many different cancers, including...
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